Murtough has pulled off big deals for stars such as Cristiano Ronaldo, Casemiro, Antony and Jadon Sancho during his tenure, but the club has struggled to match their local rivals Manchester City at the top of the table and Ratcliffe clearly feels that change is necessary at the top.
Jean-Claude Blanc, who took the reigns at Paris Saint-Germain and Juventus before joining INEOS to oversee their sporting portfolio, has been linked as a potential replacement for Murtough.
While Crystal Palace’s Dougie Freedman and Paul Mitchell have also been mentioned with the possibility of taking up roles covering recruitment at Old Trafford.
